The Lufthansa Airbus A321neo seats 215 passengers across 2 cabins. Every row below is rated on legroom, position and distance from the galleys and lavatories.
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Avoid 24D, 24E, 24F, 26C, 27A, 27B, 28B, 30D, 30E and row 37 (near lavatory), 25D, 25E, 25F, 26D, 26E, 26F, 27C, 28C, row 38 and row 39 (immediately adjacent to lavatory), 28A (exit door L4 extends into about 5% of your seat) and 29A (no window at this seat position).
The Lufthansa Airbus A321neo carries 215 passengers across Business + Economy. Seats are rated below, so you can see which have the legroom, the window alignment and the quiet — and which sit next to a galley or lavatory.
The seats rated best on this map are 1C, 16A, 16B, 16C, 16D, 16E. Another 59 seats are rated best or good. Look for exit rows 16, 18 and 12 extra-legroom seats for the most room.
Seats rated avoid on this map are 24D, 24E, 24F, 25D, 25E, 25F. Another 31 seats are rated avoid. These are usually the back rows near the galley and lavatories, or middle seats with no window or aisle.
In terms of seat size and configuration, no — the cabins are laid out the same way. Where the neo improves things is engine noise and cabin air quality; the rear rows especially benefit from the quieter new-generation engines.
Recliners arranged so the middle seat is vacant — a standard European short-haul Business product. Each passenger effectively has a window-and-aisle pair. No lie-flat beds on this aircraft.
The rearmost rows next to the galley and lavatories attract the most cabin movement throughout the flight. On a sector of two hours or more that can add up, so prioritise mid-cabin or front-of-Economy rows.